Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 Strain

Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 Strain

The attenuated Japanese encephalitis virus (JEV) strain SA14-14-2 has been successfully utilized to prevent JEV infection; however, the attenuation determinants have not been fully elucidated. The envelope (E) protein of the attenuated JEV SA14-14-2 strain differs from that of the virulent parental...

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Bibliographic Details
Main Authors: Jian Yang, Huiqiang Yang, Zhushi Li, Wei Wang, Hua Lin, Lina Liu, Qianzhi Ni, Xinyu Liu, Xianwu Zeng, Yonglin Wu, Yuhua Li
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Viruses
Subjects:
attenuation mechanism
Japanese encephalitis virus
SA14-14-2
neuroinvasiveness
neurovirulence
Online Access:http://www.mdpi.com/1999-4915/9/1/20

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http://www.mdpi.com/1999-4915/9/1/20

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