The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

Abstract Background Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. Methods We explored the role of DNA methylation in response to recent stressful life events in a cohort of bipolar patien...

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Bibliographic Details
Main Authors: Ashley L. Comes, Darina Czamara, Kristina Adorjan, Heike Anderson-Schmidt, Till F. M. Andlauer, Monika Budde, Katrin Gade, Maria Hake, Janos L. Kalman, Sergi Papiol, Daniela Reich-Erkelenz, Farah Klöhn-Saghatolislam, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Georg Juckel, Max Schmauß, Jörg Zimmermann, Jens Reimer, Eva Reininghaus, Ion-George Anghelescu, Carsten Konrad, Andreas Thiel, Christian Figge, Martin von Hagen, Manfred Koller, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Stephanie H. Witt, Sugirthan Sivalingam, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Jens Wiltfang, Peter Falkai, Thomas G. Schulze, Urs Heilbronner
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:International Journal of Bipolar Disorders
Subjects:
DNA methylation
Bipolar disorder
Stressful life events
Longitudinal
Epigenomics
Epigenetic aging
Online Access:https://doi.org/10.1186/s40345-019-0176-6

Internet

https://doi.org/10.1186/s40345-019-0176-6

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