Evolution of a key enzyme of aerobic metabolism reveals Proterozoic functional subunit duplication events and an ancient origin of animals

Abstract The biological toolkits for aerobic respiration were critical for the rise and diversification of early animals. Aerobic life forms generate ATP through the oxidation of organic molecules in a process known as Krebs’ Cycle, where the enzyme isocitrate dehydrogenase (IDH) regulates the cycle...

Full description

Bibliographic Details
Main Authors: Bruno Santos Bezerra, Flavia Ariany Belato, Beatriz Mello, Federico Brown, Christopher J. Coates, Juliana de Moraes Leme, Ricardo I. F. Trindade, Elisa Maria Costa-Paiva
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95094-4