Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Summary: Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice, dogs, and monkeys. We identify the...

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Bibliographic Details
Main Authors: Santosh K. Mishra, Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, Patrick Ralph, Jacob Coyne, Michelle Parkington, Jennifer DeBrecht, Lauren C. Ehrhardt-Humbert, Glenn P. Cruse, Wolfgang Bäumer, Ru-Rong Ji, Mei-Chuan Ko, Thierry Olivry
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720303508

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http://www.sciencedirect.com/science/article/pii/S2211124720303508

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