Atg4b-dependent autophagic flux alleviates Huntington's disease progression.

Atg4b-dependent autophagic flux alleviates Huntington's disease progression.

The accumulation of aggregated mutant huntingtin (mHtt) inclusion bodies is involved in Huntigton's disease (HD) progression. Medium sized-spiny neurons (MSNs) in the corpus striatum are highly vulnerable to mHtt aggregate accumulation and degeneration, but the mechanisms and pathways involved...

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Bibliographic Details
Main Authors: Catia C Proenca, Natacha Stoehr, Mario Bernhard, Shanon Seger, Christel Genoud, Ana Roscic, Paolo Paganetti, Shanming Liu, Leon O Murphy, Rainer Kuhn, Tewis Bouwmeester, Ivan Galimberti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3704647?pdf=render

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http://europepmc.org/articles/PMC3704647?pdf=render

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