Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration

Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration

Abstract Background Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of peptidylarginine deiminase 2 (PAD2, aka PADI2) activity appears to maintain baseme...

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Bibliographic Details
Main Authors: Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson, Scott A. Coonrod
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
Peptidylarginine deiminase 2 (PAD2)
Tumor cell migration
Ductal invasion
Mammary hyperbranching
Online Access:http://link.springer.com/article/10.1186/s12885-017-3354-x

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http://link.springer.com/article/10.1186/s12885-017-3354-x

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