Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease

Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common cause of age-related dementia leading to severe irreversible cognitive decline and massive neurodegeneration. While therapeutic approaches for managing symptoms are available, AD currently has no cure. AD associates with a progressive decline of the two ma...

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Bibliographic Details
Main Authors: Hianara A. Bustamante, Alexis E. González, Cristobal Cerda-Troncoso, Ronan Shaughnessy, Carola Otth, Andrea Soza, Patricia V. Burgos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
ubiquitin
proteasome
autophagy
lysosomes
HSV-1
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00126/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00126/full

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