JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-<mml:math alttext="$gamma$"> <mml:mi>γ</mml:mi> </mml:math>-Induced iNOS Expression and NO Production in Macrophages
<p>In inflammation, inducible nitric oxide synthase (iNOS) produces nitric oxide (NO), which modulates inflammatory processes. We investigated the effects of Janus kinase (JAK) inhibitors, AG-490 and WHI-P154, on iNOS expression and NO production in J774 murine macrophages stimulated with inte...
Format: | Article |
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Language: | English |
Published: |
Hindawi Limited
2006-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/16161 |