JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-<mml:math alttext="$gamma$"> <mml:mi>&#x03B3;</mml:mi> </mml:math>-Induced iNOS Expression and NO Production in Macrophages

<p>In inflammation, inducible nitric oxide synthase (iNOS) produces nitric oxide (NO), which modulates inflammatory processes. We investigated the effects of Janus kinase (JAK) inhibitors, AG-490 and WHI-P154, on iNOS expression and NO production in J774 murine macrophages stimulated with inte...

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Bibliographic Details
Format: Article
Language:English
Published: Hindawi Limited 2006-01-01
Series:Mediators of Inflammation
Online Access:http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/16161