Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses. Here we show that Niemann-Pick C1-like1 (NPC1L1), an NPC1 paralog and hepatitis C virus entry factor, lacks...

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Bibliographic Details
Main Authors: Esther Ndungo, John M. Dye, Sean P. Whelan, Melinda Ng, Andrew S. Herbert, Anuja Krishnan, Emily Happy Miller, Kartik Chandran
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Viruses
Subjects:
Ebola virus
Marburg virus
filovirus
viral entry
Niemann-Pick C1
NPC1
Niemann-Pick C1-like1
NPC1L1
host factor
viral receptor
Online Access:http://www.mdpi.com/1999-4915/4/11/2471

Internet

http://www.mdpi.com/1999-4915/4/11/2471

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