Novel Thiazolo[5,4-b]phenothiazine Derivatives: Synthesis, Structural Characterization, and In Vitro Evaluation of Antiproliferative Activity against Human Leukaemia

Novel Thiazolo[5,4-b]phenothiazine Derivatives: Synthesis, Structural Characterization, and In Vitro Evaluation of Antiproliferative Activity against Human Leukaemia

The molecular frame of the reported series of new polyheterocyclic compounds was intended to combine the potent phenothiazine and benzothiazole pharmacophoric units. The synthetic strategy applied was based on oxidative cyclization of N-(phenothiazin-3-yl)-thioamides and it was validated by the prep...

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Bibliographic Details
Main Authors: Balazs Brem, Emese Gal, Luiza Găină, Luminiţa Silaghi-Dumitrescu, Eva Fischer-Fodor, Ciprian Ionuţ Tomuleasa, Adriana Grozav, Valentin Zaharia, Lorena Filip, Castelia Cristea
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:International Journal of Molecular Sciences
Subjects:
phenothiazine
thiazole
antiproliferative activity
structure-activity relationship
Online Access:http://www.mdpi.com/1422-0067/18/7/1365

Internet

http://www.mdpi.com/1422-0067/18/7/1365

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