Efficient Sequencing, Assembly, and Annotation of Human KIR Haplotypes

Efficient Sequencing, Assembly, and Annotation of Human KIR Haplotypes

The homology, recombination, variation, and repetitive elements in the natural killer-cell immunoglobulin-like receptor (KIR) region has made full haplotype DNA interpretation impossible in a high-throughput workflow. Here, we present a new approach using long-read sequencing to efficiently capture,...

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Bibliographic Details
Main Authors: David Roe, Jonathan Williams, Keyton Ivery, Jenny Brouckaert, Nick Downey, Chad Locklear, Rui Kuang, Martin Maiers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
killer-cell immunoglobulin-like receptor
assembly
DNA
haplotype
annotation
natural killer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.582927/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.582927/full

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