An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [<sup>11</sup>C]PBR28 and [<sup>18</sup>F]flumazenil PET Imaging

An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [<sup>11</sup>C]PBR28 and [<sup>18</sup>F]flumazenil PET Imaging

Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emissi...

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Bibliographic Details
Main Authors: Krishna Kanta Ghosh, Parasuraman Padmanabhan, Chang-Tong Yang, Zhimin Wang, Mathangi Palanivel, Kian Chye Ng, Jia Lu, Jan Carlstedt-Duke, Christer Halldin, Balázs Gulyás
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
traumatic brain injury (TBI)
lateral fluid percussion (LFP)
positron emission tomography (PET)
neuroinflammation
GABA<sub>A</sub>-benzodiazepine receptor
PET radioligand
Online Access:https://www.mdpi.com/1422-0067/22/2/951

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https://www.mdpi.com/1422-0067/22/2/951

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