Critical Role of Hemopexin Mediated Cytoprotection in the Pathophysiology of Sickle Cell Disease

Critical Role of Hemopexin Mediated Cytoprotection in the Pathophysiology of Sickle Cell Disease

Circulating hemopexin is the primary protein responsible for the clearance of heme; therefore, it is a systemic combatant against deleterious inflammation and oxidative stress induced by the presence of free heme. This role of hemopexin is critical in hemolytic pathophysiology. In this review, we ou...

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Bibliographic Details
Main Authors: Rani Ashouri, Madison Fangman, Alicia Burris, Miriam O. Ezenwa, Diana J. Wilkie, Sylvain Doré
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
heme
heme binding protein
hemoglobinopathy
hemolysis
inflammation
immune modulation
Online Access:https://www.mdpi.com/1422-0067/22/12/6408

Internet

https://www.mdpi.com/1422-0067/22/12/6408

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