Expandable Arterial Endothelial Precursors from Human CD34+ Cells Differ in Their Proclivity to Undergo an Endothelial-to-Mesenchymal Transition

Summary: Arterial diseases continue to pose a major health concern but in vitro studies are limited because explanted cells can exhibit poor proliferative capacity and a loss of specificity. Here, we find that two transcription factors, MYCN and SOX17, induce and indefinitely expand in culture precu...

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Bibliographic Details
Main Authors: Auston Z. Miller, Alexander Satchie, Alex P. Tannenbaum, Aman Nihal, James A. Thomson, David T. Vereide
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Stem Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117305593