The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain

The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain

Upon cell stimulation, the network of cortical actin filaments is rearranged to facilitate the neurosecretory process. This actin rearrangement includes both disruption of the preexisting actin network and de novo actin polymerization. However, the mechanism by which a Ca2+ signal elicits the format...

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Bibliographic Details
Main Authors: Arlek M. González-Jamett, María J. Guerra, María J. Olivares, Valentina Haro-Acuña, Ximena Baéz-Matus, Jacqueline Vásquez-Navarrete, Fanny Momboisse, Narcisa Martinez-Quiles, Ana M. Cárdenas
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
exocytosis
fusion pore
actin polymerization
cortactin
N-WASP
neuroendocrine cells
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00130/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00130/full

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