Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics.

Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics.

T cells recognizing self-peptides that mediate autoimmune disease and those that are responsible for efficacious immunity against pathogens may differ in affinity for antigen due to central and peripheral tolerance mechanisms. Here we utilize prototypical self-reactive (myelin) and viral-specific (L...

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Bibliographic Details
Main Authors: Kristen M Rosenthal, Lindsay J Edwards, Joseph J Sabatino, Jennifer D Hood, Heather A Wasserman, Cheng Zhu, Brian D Evavold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3296730?pdf=render

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http://europepmc.org/articles/PMC3296730?pdf=render

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