Sodium Dichloroacetate Stimulates Angiogenesis by Improving Endothelial Precursor Cell Function in an AKT/GSK-3β/Nrf2 Dependent Pathway in Vascular Dementia Rats

Sodium Dichloroacetate Stimulates Angiogenesis by Improving Endothelial Precursor Cell Function in an AKT/GSK-3β/Nrf2 Dependent Pathway in Vascular Dementia Rats

Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and has been shown to display vasoprotective effects in chronic ischemic stroke. The purpose of this study was to evaluate the therapeutic effect of DCA on vascular dementia (VD) and endothelial progenitor cell...

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Bibliographic Details
Main Authors: Hui Zhao, Junqin Mao, Yuan Yuan, Jingjing Feng, Hao Cheng, Guorong Fan, Yuefan Zhang, Tiejun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
sodium dichloroacetate
endothelial progenitor cells
reactive oxygen species
angiogenesis
vascular dementia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00523/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00523/full

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