Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

Lithium, a drug used to treat bipolar disorders, has a variety of neuroprotective mechanisms including inhibition of glycogen synthase kinase-3 (GSK-3), a major tau kinase. Recently, it has been shown that, in various neurodegenerative proteinopathies, lithium could induce autophagy. To analyze how...

Full description

Bibliographic Details
Main Authors: Kohei Shimada, Yumiko Motoi, Koichi Ishiguro, Taiki Kambe, Shin-ei Matsumoto, Masako Itaya, Miyuki Kunichika, Hideo Mori, Atsuko Shinohara, Momoko Chiba, Yoshikuni Mizuno, Takashi Ueno, Nobutaka Hattori
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Tau protein
GSK-3
Lithium
Autophagy
Microtubule-associated protein 1 light chain 3
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000058

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112000058

Similar Items