Construction of Opa-positive and Opa-negative strains of Neisseria meningitidis to evaluate a novel meningococcal vaccine.

Construction of Opa-positive and Opa-negative strains of Neisseria meningitidis to evaluate a novel meningococcal vaccine.

Neisseria meningitidis is a major global pathogen causing invasive disease with a mortality of 5-10%. Most disease in developed countries is caused by serogroup B infection, against which there is no universal vaccine. Opacity-associated adhesin (Opa) proteins are major meningococcal outer membrane...

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Bibliographic Details
Main Authors: Manish Sadarangani, J Claire Hoe, Martin J Callaghan, Claire Jones, Hannah Chan, Katherine Makepeace, Hélène Daniels-Treffandier, Mary E Deadman, Christopher Bayliss, Ian Feavers, Peter van der Ley, Andrew J Pollard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3521020?pdf=render

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http://europepmc.org/articles/PMC3521020?pdf=render

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