Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease

Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease

Background: Mucosal IL-13 Receptor alpha 2 (IL13RA2) mRNA expression is one of the best predictive markers for primary non-responsiveness to infliximab therapy in patients with inflammatory bowel disease (IBD). The objective of this study was to understand how IL-13Rα2, a negative regulator of IL-13...

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Bibliographic Details
Main Authors: Bram Verstockt, Clémentine Perrier, Gert De Hertogh, Jonathan Cremer, Brecht Creyns, Gert Van Assche, Marc Ferrante, Jan L. Ceuppens, Séverine Vermeire, Christine Breynaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
IL13RA2
goblet cells
anti-TNF non-responsiveness
IBD
inflammatory bowel disease
infliximab
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02983/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02983/full

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