De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome

De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome

Background: Brugada syndrome (BrS) is a genetically determined cardiac electrical disorder, characterized by typical electrocardiography (ECG) alterations, and it is an arrhythmogenic syndrome that may lead to sudden cardiac death. The most common genotype found among BrS patients is caused by mutat...

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Bibliographic Details
Main Authors: Lumin Wang, Xiangyun Meng, Zhiguang Yuchi, Zhenghang Zhao, Dehui Xu, David Fedida, Zhuren Wang, Chen Huang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
SCN5A
Sodium Channel Gating
Brugada Syndrome
Arrhythmia
Cardiac depolarization
Ion channel trafficking
Online Access:http://www.karger.com/Article/FullText/430189

Internet

http://www.karger.com/Article/FullText/430189

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