Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential mechanistic role of Cdc6 ATP hydrolysis in this reaction is still incompletely understood. Here, w...

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Bibliographic Details
Main Authors: FuJung Chang, Alberto Riera, Cecile Evrin, Jingchuan Sun, Huilin Li, Christian Speck, Michael Weinreich
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
DNA replication
ORC/Cdc6
helicase loader
AAA+ ATPase
Online Access:https://elifesciences.org/articles/05795

Internet

https://elifesciences.org/articles/05795

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