Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-08986-5 |