Enhanced Internalization of Nanoparticles Following Ionizing Radiation Leads to Mitotic Catastrophe in MG-63 Human Osteosarcoma Cells

Enhanced Internalization of Nanoparticles Following Ionizing Radiation Leads to Mitotic Catastrophe in MG-63 Human Osteosarcoma Cells

This study aims to investigate whether ionizing radiation combined with doxorubicin-conjugated iron oxide nanoparticles (NP-DOX) improves the internalization and cytotoxic effects of the nano-carrier-mediated drug delivery in MG-63 human osteosarcoma cells. NP-DOX was designed and synthesized using...

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Bibliographic Details
Main Authors: Roxana Cristina Popescu, Mihai Straticiuc, Cosmin Mustăciosu, Mihaela Temelie, Roxana Trușcă, Bogdan Ștefan Vasile, Adina Boldeiu, Dragoş Mirea, Radu Florin Andrei, Constantin Cenușă, Laurenţiu Mogoantă, George Dan Mogoșanu, Ecaterina Andronescu, Mihai Radu, Marlon R. Veldwijk, Diana Iulia Savu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
MG-63 osteosarcoma
ionizing radiation
iron oxide nanoparticles
doxorubicin
combined antitumor treatment
Online Access:https://www.mdpi.com/1422-0067/21/19/7220

Internet

https://www.mdpi.com/1422-0067/21/19/7220

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