NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferation.

NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferation.

The majority of chronic myeloid leukemia (CML) cases are caused by a chromosomal translocation linking the breakpoint cluster region (BCR) gene to the Abelson murine leukemia viral oncogene-1 (ABL1), creating the mutant fusion protein BCR-ABL1. Downstream of BCR-ABL1 is growth factor receptor-bound...

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Bibliographic Details
Main Authors: Tina R Lewis, Jesse Smith, Kallie Griffin, Stephanie Aguiar, Kristen F Rueb, Natalie Holmberg-Douglas, Ellen M Sampson, Skylar Tomasetti, Sofia Rodriguez, David L Stachura, Carolynn C Arpin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236839

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https://doi.org/10.1371/journal.pone.0236839

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