Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss

Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss

Objective: The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown. As hypothalamic melanocortin neuropeptide Y/agouti-r...

Full description

Bibliographic Details
Main Authors: Natalie Jane Michael, Stephanie Elise Simonds, Marco van den Top, Michael Alexander Cowley, David Spanswick
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
Mitochondrial uncoupling
NPY
POMC
Weight-loss
BAT thermogenesis
ATP-sensitive potassium channel
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817302958

Internet

http://www.sciencedirect.com/science/article/pii/S2212877817302958

Similar Items