Induction of the Tumor-Suppressor p16INK4a within Regenerative Epithelial Crypts in Ulcerative Colitis

Induction of the Tumor-Suppressor p16INK4a within Regenerative Epithelial Crypts in Ulcerative Colitis

p16INK4a is a major tumor-suppressor protein, but its regulation and settings of fuction remain poorly understood. To explore the notion that p16 is induced in vivo in response to replicative stress, we examined p16 expression in tissues from human ulcerative colitis (UC; n = 25) and normal control...

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Bibliographic Details
Main Authors: Emma E. Furth, Karen S. Gustafson, Charlotte Y. Dai, Steven L. Gibson, Paul Menard-Katcher, Tina Chen, Jim Koh, Greg H. Enders
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
p16
INK4a
ulcerative colitis
tumor suppressor
DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800254

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http://www.sciencedirect.com/science/article/pii/S1476558606800254

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