Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

Summary: This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We...

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Main Authors: Emanuela S. Fioretta, PhD, Valentina Lintas, PhD, Anna Mallone, PhD, Sarah E. Motta, PhD, Lisa von Boehmer, DVM, Petra E. Dijkman, PhD, Nikola Cesarovic, DVM, PhD, Etem Caliskan, MD, Héctor Rodriguez Cetina Biefer, MD, Miriam Lipiski, DVM, Mareike Sauer, DVM, Matilde Putti, PhD, Henk M. Janssen, PhD, Serge H. Söntjens, PhD, Anthal I.P.M. Smits, PhD, Carlijn V.C. Bouten, PhD, Maximilian Y. Emmert, MD, PhD, Simon P. Hoerstrup, MD, PhD
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19303109

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http://www.sciencedirect.com/science/article/pii/S2452302X19303109

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