Quantification of T-Cell and B-Cell Replication History in Aging, Immunodeficiency, and Newborn Screening

Quantification of T-Cell and B-Cell Replication History in Aging, Immunodeficiency, and Newborn Screening

Quantification of T-cell receptor excision circles (TRECs) has impacted on human T-cell research, but interpretations on T-cell replication have been limited due to the lack of a genomic coding joint. We here overcome this limitation with multiplex TRG rearrangement quantification (detecting ~0.98 a...

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Bibliographic Details
Main Authors: Ruud H. J. Verstegen, Pei M. Aui, Eliza Watson, Samuel De Jong, Sophinus J. W. Bartol, Julian J. Bosco, Paul U. Cameron, Robert G. Stirling, Esther de Vries, Jacques J. M. van Dongen, Menno C. van Zelm
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
T-cell replication
TREC
TRG
primary immunodeficiency
newborn screening
aging
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02084/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02084/full

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