Screening of Compounds for Anti-tuberculosis Activity, and in vitro and in vivo Evaluation of Potential Candidates

Tuberculosis (TB) is a debilitating infectious disease responsible for more than one million deaths per year. The emergence of drug-resistant TB poses an urgent need for the development of new anti-TB drugs. In this study, we screened a library of over 4,000 small molecules and found that orbifloxac...

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Bibliographic Details
Main Authors: Wei Zhou, Bing Yang, Yanyan Zou, Khaista Rahman, Xiaojian Cao, Yingying Lei, Ren Lai, Zhen F. Fu, Xi Chen, Gang Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.658637/full