Proteomics Is Analytical Chemistry: Fitness-for-Purpose in the Application of Top-Down and Bottom-Up Analyses

Molecular mechanisms underlying health and disease function at least in part based on the flexibility and fine-tuning afforded by protein isoforms and post-translational modifications. The ability to effectively and consistently resolve these protein species or proteoforms, as well as assess quantit...

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Bibliographic Details
Main Authors: Jens R. Coorssen, Alfred L. Yergey
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Proteomes
Subjects:
2DE
Online Access:http://www.mdpi.com/2227-7382/3/4/440