Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy

Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy

Activation of the lysosomal ceramide-producing enzyme, acid sphingomyelinase (ASM), by various stresses is centrally involved in cell death and has been implicated in autophagy. We set out to investigate the role of the baseline ASM activity in maintaining physiological functions of lysosomes, focus...

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Bibliographic Details
Main Authors: Matthew J. Justice, Irina Bronova, Kelly S. Schweitzer, Christophe Poirier, Janice S. Blum, Evgeny V. Berdyshev, Irina Petrache
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Lipid Research
Subjects:
lysosome
sphingolipids
membrane
endothelial cells
lung
sphingosine
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339110

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http://www.sciencedirect.com/science/article/pii/S0022227520339110

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