Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Receptor tyrosine kinases (RTKs) are major players in signal transduction, regulating cellular activities in both normal regeneration and malignancy. Thus, many RTKs, c-Kit among them, play key roles in the function of both normal and neoplastic cells, and as such constitute attractive targets for t...

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Bibliographic Details
Main Authors: Tal Tilayov, Tal Hingaly, Yariv Greenshpan, Shira Cohen, Barak Akabayov, Roi Gazit, Niv Papo
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
receptor tyrosine kinases
protein-protein interactions
protein engineering
directed evolution
angiogenesis
binding affinity
Online Access:https://www.mdpi.com/1420-3049/25/20/4850

Internet

https://www.mdpi.com/1420-3049/25/20/4850

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