α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation

α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation

BackgroundTemporal lobe epilepsy (TLE) is one of the most drug-resistant types of epilepsy with about 80% of TLE patients falling into this category. Increasing evidence suggests that neuroinflammation, which has a critical role in the epileptogenesis of TLE, is associated with microglial activation...

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Bibliographic Details
Main Authors: Hui-juan Liu, Xin Lai, Yan Xu, Jing-kun Miao, Chun Li, Jing-ying Liu, Yuan-yuan Hua, Qian Ma, Qixiong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neurology
Subjects:
α-asarone
epilepsy
microglia
inflammation
nuclear factor-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00661/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00661/full

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