Identification of the Neurokinin-1 Receptor as Targetable Stratification Factor for Drug Repurposing in Pancreatic Cancer

Identification of the Neurokinin-1 Receptor as Targetable Stratification Factor for Drug Repurposing in Pancreatic Cancer

The SP/NK1R-complex plays an important role in tumor proliferation. Targeting of the neurokinin-1 receptor in previous studies with its antagonist aprepitant (AP) resulted in anti-tumoral effects in colorectal cancer and hepatoblastoma. However, there is still a lack of knowledge regarding its effec...

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Bibliographic Details
Main Authors: Iris Beirith, Bernhard W. Renz, Shristee Mudusetti, Natalja Sergejewna Ring, Julian Kolorz, Dominik Koch, Alexandr V. Bazhin, Michael Berger, Jing Wang, Martin K. Angele, Jan G. D’Haese, Markus O. Guba, Hanno Niess, Joachim Andrassy, Jens Werner, Matthias Ilmer
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
PDAC
neurokinin-1 receptor
NK1R
TACR1
substance P
Online Access:https://www.mdpi.com/2072-6694/13/11/2703

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https://www.mdpi.com/2072-6694/13/11/2703

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