In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies.

In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies.

Drug toxicity observed in animal studies during drug development accounts for the discontinuation of many drug candidates, with the kidney being a major site of tissue damage. Extensive investigations are often required to reveal the mechanisms underlying such toxicological events and in the case of...

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Bibliographic Details
Main Authors: Anna Nilsson, Benita Forngren, Sivert Bjurström, Richard J A Goodwin, Elisa Basmaci, Ingela Gustafsson, Anita Annas, Dennis Hellgren, Alexander Svanhagen, Per E Andrén, Johan Lindberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3479109?pdf=render

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http://europepmc.org/articles/PMC3479109?pdf=render

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