Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.

Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.

<h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other conte...

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Bibliographic Details
Main Authors: Rajamanickam Anuradha, Parakkal Jovvian George, Luke E Hanna, Vedachalam Chandrasekaran, P Paul Kumaran, Thomas B Nutman, Subash Babu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498448/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498448/?tool=EBI

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