Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.
<h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other conte...
Main Authors: | Rajamanickam Anuradha, Parakkal Jovvian George, Luke E Hanna, Vedachalam Chandrasekaran, P Paul Kumaran, Thomas B Nutman, Subash Babu |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498448/?tool=EBI |
Similar Items
-
Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis.
by: Rajamanickam Anuradha, et al.
Published: (2014-04-01) -
IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection.
by: Rajamanickam Anuradha, et al.
Published: (2016-01-01) -
Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10.
by: Parakkal Jovvian George, et al.
Published: (2014-09-01) -
Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease.
by: Rajamanickam Anuradha, et al.
Published: (2012-01-01) -
Review of Dancing Parasites in Lymphatic Filariasis
by: Christoph F. Dietrich, et al.
Published: (2019-03-01)