The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia

The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia

Radiation-induced bystander effects (RIBE) may have potential implications for radiotherapy, yet the radiobiological impact and underlying mechanisms in hypoxic tumor cells remain to be determined. Using two human tumor cell lines, hepatoma HepG2 cells and glioblastoma T98G cells, the present study...

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Bibliographic Details
Main Authors: Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl Butterworth, Chunlin Shao, Kevin M. Prise
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
radiation
hypoxia
bystander
HIF1 alpha
micronuclei
hepatoma cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.637454/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.637454/full

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