Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease

Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease

Background: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in patients is due to the disease progression itself, or is affected by L-DOPA replacement...

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Bibliographic Details
Main Authors: Si-Yue Li, Ya-Li Wang, Wen-Wen Liu, Dong-Jun Lyu, Fen Wang, Cheng-Jie Mao, Ya-Ping Yang, Li-Fang Hu, Chun-Feng Liu
Format: Article
Language:English
Published: Wolters Kluwer 2017-01-01
Series:Chinese Medical Journal
Subjects:
Circadian Rhythm; Levodopa; Oxidopamine; Parkinson Disease
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=9;spage=1085;epage=1092;aulast=Li

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http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=9;spage=1085;epage=1092;aulast=Li

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