A physiologically based model of orexinergic stabilization of sleep and wake.

The orexinergic neurons of the lateral hypothalamus (Orx) are essential for regulating sleep-wake dynamics, and their loss causes narcolepsy, a disorder characterized by severe instability of sleep and wake states. However, the mechanisms through which Orx stabilize sleep and wake are not well under...

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Bibliographic Details
Main Authors: Ben D Fulcher, Andrew J K Phillips, Svetlana Postnova, Peter A Robinson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651580/?tool=EBI