Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.

Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.

Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2AK119u1) and trimethylation of H3 lysine 27 (H3K27...

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Bibliographic Details
Main Authors: Mitsuhiro Endoh, Takaho A Endo, Tamie Endoh, Kyo-ichi Isono, Jafar Sharif, Osamu Ohara, Tetsuro Toyoda, Takashi Ito, Ragnhild Eskeland, Wendy A Bickmore, Miguel Vidal, Bradley E Bernstein, Haruhiko Koseki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3405999?pdf=render

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http://europepmc.org/articles/PMC3405999?pdf=render

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