Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Abstract Park2 is an E3 ubiquitin ligase known for its role in mitochondrial quality control via the mitophagy pathway. Park2 KO mice are protected from diet‐induced obesity and hepatic insulin sensitivity is improved in high‐fat diet (HFD)‐fed Park2 KO mice even under body weight‐matched conditions...

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Bibliographic Details
Main Authors: Lia R. Edmunds, Brydie R. Huckestein, Mario Kahn, Dongyan Zhang, Yanxia Chu, Yingze Zhang, Stacy G. Wendell, Gerald I. Shulman, Michael J. Jurczak
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Physiological Reports
Subjects:
AMPK
diacylglycerol
IL6
insulin resistance
liver
mitophagy
Online Access:https://doi.org/10.14814/phy2.14281

Internet

https://doi.org/10.14814/phy2.14281

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