Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates.

Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates.

Resistance mutations to the HIV-1 fusion inhibitor enfuvirtide emerge mainly within the drug's target region, HR1, and compensatory mutations have been described within HR2. The surrounding envelope (env) genetic context might also contribute to resistance, although to what extent and through w...

Full description

Bibliographic Details
Main Authors: Franky Baatz, Monique Nijhuis, Morgane Lemaire, Martiene Riedijk, Annemarie M J Wensing, Jean-Yves Servais, Petra M van Ham, Andy I M Hoepelman, Peter P Koopmans, Herman G Sprenger, Carole Devaux, Jean-Claude Schmit, Danielle Perez Bercoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3132734?pdf=render

Internet

http://europepmc.org/articles/PMC3132734?pdf=render

Similar Items