GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

Summary: We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family of cytokines, maintains Ewing sarcoma growth by preventing Src hyperactivation. Surprisingly, Ewing sarcoma depends on the prodomain, n...

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Bibliographic Details
Main Authors: Fuchun Zhou, David J. Elzi, Panneerselvam Jayabal, Xiuye Ma, Yu-Chiao Chiu, Yidong Chen, Barron Blackman, Susan T. Weintraub, Peter J. Houghton, Yuzuru Shiio
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
GDF6
CD99
Src
CSK
Ewing sarcoma
Klippel-Feil syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313218

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http://www.sciencedirect.com/science/article/pii/S2211124720313218

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