GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth
Summary: We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family of cytokines, maintains Ewing sarcoma growth by preventing Src hyperactivation. Surprisingly, Ewing sarcoma depends on the prodomain, n...
Main Authors: | Fuchun Zhou, David J. Elzi, Panneerselvam Jayabal, Xiuye Ma, Yu-Chiao Chiu, Yidong Chen, Barron Blackman, Susan T. Weintraub, Peter J. Houghton, Yuzuru Shiio |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-11-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124720313218 |
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