Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

A new series of hybrid compounds with tropinone and thiazole rings in the structure was designed and synthesized as potential anticancer agents. They were tested against human multiple myeloma (RPMI 8226), lung carcinoma (A549), breast adenocarcinoma (MDA-MB-231), and mouse skin melanoma (B16-F10) c...

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Bibliographic Details
Main Authors: Katarzyna Piechowska, Magdalena Mizerska-Kowalska, Barbara Zdzisińska, Joanna Cytarska, Angelika Baranowska-Łączkowska, Karol Jaroch, Kamil Łuczykowski, Wojciech Płaziński, Barbara Bojko, Stefan Kruszewski, Konrad Misiura, Krzysztof Z. Łączkowski
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
cancer
multiple myeloma
melanoma
tropinone
thiazole
mushroom tyrosinase
Online Access:https://www.mdpi.com/1422-0067/21/23/9050

Internet

https://www.mdpi.com/1422-0067/21/23/9050

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