DNA translocation mechanism of the MCM complex and implications for replication initiation
Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combination of ADP, and ATP-mimic, ADP-BeF3.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11074-3 |