Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling

Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling

Inflammatory caspase-11 senses and is activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis that has critical role in defensing against bacterial infection, whereas its excess activation under pathogenic circumstances may cause various inflammatory diseases. However, there are fe...

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Bibliographic Details
Main Authors: Jiezhou Ye, Bo Zeng, Meiyan Zhong, Hongchun Li, Lihui Xu, Junxiang Shu, Yaofeng Wang, Fan Yang, Chunsu Zhong, Xunjia Ye, Xianhui He, Dongyun Ouyang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Caspase-11
Macrophages
Gasdermin D
Pyroptosis
Scutellarin
PKA signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306560

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http://www.sciencedirect.com/science/article/pii/S2211383520306560

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