ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei

ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei

DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a checkpoint response to delay cell cycle progr...

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Bibliographic Details
Main Authors: Paula Andrea Marin, Ricardo Obonaga, Raphael Souza Pavani, Marcelo Santos da Silva, Christiane Bezerra de Araujo, André Arruda Lima, Carla Cristi Avila, Igor Cestari, Carlos Renato Machado, Maria Carolina Elias
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ATR
DNA damage response
checkpoint
γH2A
RAD51
Trypanosoma brucei
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.602956/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.602956/full

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